Aloe vera and its potency as antituberculosis against strains of Mycobacterium tuberculosis that is resistant to some tuberculosis drugs

نویسندگان

چکیده

Introduction: Aloe vera has anti-bacterial ability against Gram-positive and Gram-negative bacteria; however, study, especially in multidrug resistant strain of Mycobacterium tuberculosis, not been evaluated yet. This study aims to determine the potential as an antituberculosis drug-resistant strains tuberculosis. Method: Stages research include production ethanol extract vera, then testing phytochemicals (identification alkaloids, steroids/triterpenoids, anthraquinone, flavonoids, saponins, tannins) chemical content by thin layer chromatography (TLC). The test for tuberculosis was performed on Lowenstein Jensen media. Results: Test results showed qualitative identification, TLC contains tannins. Antioxidant activity DPPH radical shows IC50 value 6927.133 ppm. Tuberculosis H37Rv MDR TB HE (resistant INH Ethambutol), SR streptomycin Rifampicin) inhibition ranging concentration 50 mg/mL all extracts well sensitivity, a sensitive start extracts. Conclusions: tannins that act antioxidants are anti-tuberculosis drugs.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Salicylate reduces susceptibility of Mycobacterium tuberculosis to multiple antituberculosis drugs.

Salicylate induces multiple antibiotic resistance in various bacterial species. Here we investigated the effect of salicylate on the susceptibility of Mycobacterium tuberculosis to a range of antituberculosis (anti-TB) drugs. In the presence of salicylate, the killing effects of isoniazid (INH), rifampin (RMP), ethambutol (EMB), streptomycin (STR), and p-aminosalicylate (PAS) were reduced, as s...

متن کامل

Primary drug resistance of Mycobacterium tuberculosis to antituberculosis drugs.

Thirty two positive sputa from 104 untreated cases of pulmonary tuberculosis, were tested for sensitivities against antituberculosis drugs. Twenty four were positive on direct smear as well as culture while 8 were only culture positive. Nine (28%) were resistant to Isoniazid, 3 (9.4%) to Streptomycin and 2 (6.3%) were resistant to both the drugs. All the 32 were sensitive to Rifampicin and Etha...

متن کامل

Mycobacterium tuberculosis resistance to antituberculosis drugs in Mozambique*, **

OBJECTIVE To determine the drug resistance profile of Mycobacterium tuberculosis in Mozambique. METHODS We analyzed secondary data from the National Tuberculosis Referral Laboratory, in the city of Maputo, Mozambique, and from the Beira Regional Tuberculosis Referral Laboratory, in the city of Beira, Mozambique. The data were based on culture-positive samples submitted to first-line drug susc...

متن کامل

In vitro susceptibility testing of Mycobacterium tuberculosis complex strains isolated from seals to antituberculosis drugs.

Mycobacteria strains belonging to the Mycobacterium tuberculosis complex were isolated from seals found in the South Atlantic. The animals were received in Mundo Marino installations and treated for Mycobacterium tuberculosis complex by conventional therapy of intensive care and enriched food supply; however, in all cases treatment failed. Necropsies of all animals revealed extensive lesions co...

متن کامل

Infectiousness of drug-resistant Mycobacterium tuberculosis strains

October 2007, Vol. 97, No. 10 SAMJ Drug-resistant tuberculosis (TB), and especially multidrugresistant (MDR) TB (i.e. resistance to isoniazid and rifampicin with or without resistance to other drugs) or extensively drug-resistant (XDR) TB (i.e. MDR resistance plus resistance to the fluoroquinolones and one of the second-line injectables – kanamycin, amikacin or capreomycin),1 has very important...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Bali Medical Journal

سال: 2022

ISSN: ['2089-1180', '2302-2914']

DOI: https://doi.org/10.15562/bmj.v11i3.3644